Therapeutically blocking Interleukin-11 Receptor-a enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours
Amy Winship, Michelle Van Sinderen, Katarzyna Rainczuk, Evdokia Dimitriadis
ONCOTARGET | IMPACT JOURNALS LLC | Published : 2017
High grade type I endometrial cancers have poor prognosis. Interleukin (IL)11 is elevated in tumours and uterine lavage with increasing tumour grade in women. IL11 regulates cell cycle, invasion and migration and we recently demonstrated that IL11 receptor (R)α inhibition impaired low and moderate grade endometrial tumourigenesis in vivo. In this report, we hypothesized that micro-RNA(miR)-1 regulates IL11 and that IL11 promotes high grade endometrial tumour growth. We aimed to determine whether combination treatment using an anti-human IL11Rα blocking antibody (Ab) and doxorubicin chemotherapeutic impairs high grade tumour growth. MiR-1 was absent in human endometrial tumours versus human b..View full abstract
Awarded by National Health and Medical Research Council Senior Research Fellowship
We acknowledge the support of the Victorian Government's Operational Infrastructure Support Program. ED was supported by a National Health and Medical Research Council Senior Research Fellowship (#550905). AW was supported by a Cancer Council Victoria Postdoctoral Fellowship.