Fertile ground: human endometrial programming and lessons in health and disease
Jemma Evans, Lois A Salamonsen, Amy Winship, Ellen Menkhorst, Guiying Nie, Caroline E Gargett, Eva Dimitriadis
NATURE REVIEWS ENDOCRINOLOGY | NATURE PUBLISHING GROUP | Published : 2016
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under the orchestration of oestrogen and progesterone, in preparation for embryo implantation. Humans are among the very few species that menstruate and that, consequently, are equipped with unique cellular and molecular mechanisms controlling these cyclic processes. Many reproductive pathologies are specific to menstruating species, and studies in animal models rarely translate to humans. Abnormal remodelling and regeneration of the human endometrium leads to a range of reproductive complications. Furthermore, the processes regulating endometrial remodelling and implanta..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
The authors are grateful for funding from National Health and Medical Research Council (NHMRC) of Australia Project Grants to J.E., L.A.S., C.E G., E.D. and E.M. (grants 1081944, 1085435,1098321 and 1098332), a Senior Principal Research Fellowship to L.A.S. (grant 1002028), Senior Research Fellowships to E.D. (grant 1019826), G N. (grant 494808) and C.E.G. (grant 1042298), a Cancer Council of Victoria Fellowship to A.W. and the Victorian Infrastructure Support Program and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.