Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation
Amy Louise Winship, Kate Rainczuk, Amanda Ton, Eva Dimitriadis
ONCOLOGY LETTERS | SPANDIDOS PUBL LTD | Published : 2016
Endometrial cancer is the most common invasive gynaecological malignancy. While endocrine, genetic and inflammatory factors are thought to contribute to its pathogenesis, its precise etiology and molecular regulators remain poorly understood. Fibulin-5 is an extracellular matrix (ECM) protein that inhibits cell growth and invasion in several cancer cell types and is downregulated in a number of types of human cancer. However, it is unknown whether fibulin-5 plays a role in endometrial tumourigenesis. In the current report, the expression and localisation of fibulin-5 in type I endometrioid human endometrial cancers of grades (G) 1-3 was investigated using reverse transcription-quantitative p..View full abstract
Awarded by NHMRC
The authors would like to acknowledge the support of the Victorian Government's Operational Infrastructure Support Program and the Australian Government National Health and Medical Research Council (NHMRC) Independent Research Institute Infrastructure Support Scheme. Professor Eva Dimitriadis was supported by an NHMRC Fellowship (11550905). Miss Amy Winship was supported by an Australian Postgraduate Award.