Localisation of the Notch family in the human endometrium of fertile and infertile women
Michelle Van Sinderen, Carly Cuman, Thilini Gamage, Katarzyna Rainczuk, Tiki Osianlis, Luk Rombauts, Evdokia Dimitriadis
JOURNAL OF MOLECULAR HISTOLOGY | SPRINGER | Published : 2014
To investigate the spatial and temporal immunolocalisation and staining intensity of the Notch signalling family in endometrium of fertile and infertile women, endometrial biopsies were collected by curettage from 25 fertile women across the menstrual cycle and 10 infertile women in the mid secretory phase of menstrual cycle. Immunohisotchemistry was completed for NOTCH1, -2, -3, -4, cleaved Notch, DLL1, -3, -4, JAGGED1, -2, HES and NUMB and immunostaining intensity measured in both the endometrial glandular and luminal epithelium. NOTCH1 and the ligands DLL1 and JAGGED1 were key proteins displaying increased staining intensity during the receptive phase of the menstrual cycle and dysregulat..View full abstract
Awarded by NHMRC (Australia) Project Grant
Awarded by NHMRC (Australia) Senior Research Fellowship
This work was supported by NHMRC (Australia) Project Grant (#1027100) and by the Victorian Government's Operational Infrastructure Support Program. ED was supported by NHMRC (Australia) Senior Research Fellowship (#550905).