Galectin-7 is important for normal uterine repair following menstruation
Jemma Evans, Joanne Yap, Thillini Gamage, Lois Salamonsen, Evdokia Dimitriadis, Ellen Menkhorst
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2014
Menstruation involves the shedding of the functional layer of the endometrium in the absence of pregnancy. At sites where tissue shedding is complete, re-epithelialization of the tissue is essential for repair and termination of bleeding. The complement of growth factors that mediate post-menstrual endometrial repair are yet to be completely elucidated. Galectins regulate many cell functions important for post-menstrual repair, such as cell adhesion and migration. Galectin-7 has a well characterized role in re-epithelialization and wound healing. We hypothesized that galectin-7 would be important in re-epithelialization during post-menstrual repair. We aimed to identify endometrial expressio..View full abstract
Awarded by National Heath and Medical Research Council (Australia)
This work was supported by National Heath and Medical Research Council (Australia) Project/Program Grants (#1027100 to E.D. and E.M., #494802 to L.S., #1047756 to L.S. and J.E.; Fellowship grants #1002028 to L.S., #550905 to E.D., #611827 to E.M.) and by the Victorian Government's Operational Infrastructure Support Program.