Journal article

Galectin-7 is important for normal uterine repair following menstruation

Jemma Evans, Joanne Yap, Thillini Gamage, Lois Salamonsen, Evdokia Dimitriadis, Ellen Menkhorst

MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2014

Abstract

Menstruation involves the shedding of the functional layer of the endometrium in the absence of pregnancy. At sites where tissue shedding is complete, re-epithelialization of the tissue is essential for repair and termination of bleeding. The complement of growth factors that mediate post-menstrual endometrial repair are yet to be completely elucidated. Galectins regulate many cell functions important for post-menstrual repair, such as cell adhesion and migration. Galectin-7 has a well characterized role in re-epithelialization and wound healing. We hypothesized that galectin-7 would be important in re-epithelialization during post-menstrual repair. We aimed to identify endometrial expressio..

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Grants

Awarded by National Heath and Medical Research Council (Australia)


Funding Acknowledgements

This work was supported by National Heath and Medical Research Council (Australia) Project/Program Grants (#1027100 to E.D. and E.M., #494802 to L.S., #1047756 to L.S. and J.E.; Fellowship grants #1002028 to L.S., #550905 to E.D., #611827 to E.M.) and by the Victorian Government's Operational Infrastructure Support Program.