Interleukin 11: similar or opposite roles in female reproduction and reproductive cancer?
Amy Winship, Ellen Menkhorst, Michelle Van Sinderen, Evdokia Dimitriadis
REPRODUCTION FERTILITY AND DEVELOPMENT | CSIRO PUBLISHING | Published : 2016
During placental development and carcinogenesis, cell invasion and migration are critical events in establishing a self-supporting vascular supply. Interleukin (IL)-11 is a pleiotropic cytokine that affects the invasive and migratory capabilities of trophoblast cells that form the placenta during pregnancy, as well as various malignant cell types. The endometrium is the site of embryo implantation during pregnancy; conversely, endometrial carcinoma is the most common gynaecological malignancy. Here, we review what is known about the role of IL-11 in trophoblast function and in gynaecological malignancies, focusing primarily on the context of the uterine environment.
Awarded by National Health and Medical Research Council of Australia (NHMRC) Early Career (Postdoctoral) Fellowship
Awarded by NHMRC Senior Research Fellowship
The authors thank Sue Panckridge for her assistance with the preparation of the figure. The authors' work reported herein was supported by the Victorian Government's Operational Infrastructure Support Program. EM was supported by a National Health and Medical Research Council of Australia (NHMRC) Early Career (Postdoctoral) Fellowship (#611827). ED was supported by an NHMRC Senior Research Fellowship (#550905).