Journal article

The chrondroitin sulfate proteoglycan (CSPG4) regulates human trophoblast function

M Van Sinderen, C Cuman, A Winship, E Menkhorst, E Dimitriadis

PLACENTA | W B SAUNDERS CO LTD | Published : 2013

Abstract

INTRODUCTION: Trophoblast growth and invasion of the uterine endometrium are critical events during placentation and are tightly regulated by locally produced factors. Abnormal placentation can result in early miscarriage or preeclampsia and intrauterine growth restriction, leading to impaired fetal and/or maternal health. Chondroitin sulfate proteoglycan 4 (CSPG4) is involved in cancer cell migration and invasion, processes which are critical during placentation but unlike in cancer, trophoblast invasion is highly regulated. CSPG4 expression and function in trophoblast is unknown. We determined CSPG4 expression in human first trimester placenta and implantation sites, and investigated wheth..

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Grants

Awarded by NHMRC (Australia)


Awarded by NHMRC (Australia) Senior Research Fellowship (GNT)


Awarded by NHMRC (Australia) Early Career (Postdoctoral) Fellowship (GNT)


Funding Acknowledgements

This work was supported by NHMRC (Australia) Project Grant (GNT1027100) to ED and EM and by the Victorian Government's Operational Infrastructure Support Program. ED was supported by NHMRC (Australia) Senior Research Fellowship (GNT#550905). EM was supported by NHMRC (Australia) Early Career (Postdoctoral) Fellowship (GNT#611827). The authors would like to acknowledge the contribution of Ms Judi Hocking for the consenting of patients and collection of tissues. We would also like to thank Dr Stefan Sonderegger for his technical advice. PHI data audit 13-22.