Journal article

IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Lavanya Balakrishnan, Sowmya Soman, Yatish B Patil, Jayshree Advani, Joji Kurian Thomas, Dattatraya Venkatesh Desai, Urmila Kulkarni-Kale, HC Harsha, TS Keshava Prasad, Rajesh Raju, Akhilesh Pandey, Eva Dimitriadis, Aditi Chatterjee



Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 trans..

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Funding Acknowledgements

We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics, Bangalore. Dattatraya Venkatesh Desai and Urmila Kulkarni-Kale gratefully acknowledge the facilities of the Bioinformatics Centre, University of Pune and the "Centre of Excellence" grant by the Department of Biotechnology (DBT), Government of India as well as the Department of Information Technology (DIT), Government of India. HC Harsha is a Wellcome Trust/DBT India Alliance Early Career Fellow. Eva Dimitriadis was supported by the National Health and Medical Research Council (NHMRC) of Australia.