Journal article

Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity

Reza Nejatbakhsh, Maryam Kabir-Salmani, Eva Dimitriadis, Ahmad Hosseini, Robabeh Taheripanah, Yousef Sadeghi, Yoshihiro Akimoto, Mitsutoshi Iwashita



BACKGROUND: Apical surfaces of human endometrial epithelium and endothelium are key elements for the initiation of molecular interactions to capture the blastocyst or leukocyte, respectively. The L-selectin adhesion system has been strongly proposed to play an important role in the initial steps of trophoblast adhesion and promotion of integrin-dependent processes, ultimately culminating in the establishment of the embryo-maternal interface. On the basis of these facts, we hypothesized a novel role for pinopodes as the first embryo-fetal contact sites to contain the highest subcellular expression of L-selectin ligand suggesting its role in early adhesion as predicted. Thus, the objective of ..

View full abstract


Awarded by NHMRC fellowship

Awarded by Grants-in-Aid for Scientific Research

Funding Acknowledgements

We thank Dr Stefan Sonderegger for assistance with the Western blot methodology. This work is supported by a grant from National Institute of Genetic Engineering and Biotechnology and Shaheed Beheshti University of Medical Sciences to MKS (It is part of Ph.D student thesis Reza Nejatbakhsh in Shaheed Beheshti University of Medical Sciences, Tehran, Iran). ED is the funding recipient of an NHMRC fellowship #550905 and project grant #388901. ED was supported by the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.