Journal article
Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts.
S Sonderegger, J Yap, E Menkhorst, G Weston, PG Stanton, E Dimitriadis
Human Reproduction Oxford England | OXFORD UNIV PRESS | Published : 2011
Abstract
Human trophoblast invasion and differentiation are essential for a successful pregnancy outcome. Dysregulation of these processes can lead to placental pathologies such as pre-eclampsia. The molecular mechanisms; however, are poorly understood. Interleukin (IL)11--a cytokine that regulates endometrial epithelial cell adhesion, trophoblast motility and invasion during implantation--may be involved in some of these processes. The effect of IL11 on protein expression was investigated in trophoblastic HTR8/SVneo cells and primary extravillous trophoblasts (EVTs) purified from first- trimester placentas. Two-dimension (2D)-differential in-gel electrophoresis analyses revealed that 731 spots were ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia: E.D. is the funding recipient of fellowship #550905 and project grant #388901; S.S. and J.Y. are founded by project grant #388901; E.M. is founded by fellowship #611827, P.S. is the recipient of program grant #494802. The study was also supported by the Victorian Government's Operational Infrastructure Support Program. PHI Data Audit 10-33.