Journal article

Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success

C Cuman, EM Menkhorst, LJ Rombauts, S Holden, D Webster, M Bilandzic, T Osianlis, E Dimitriadis



STUDY QUESTION: Do human blastocysts which subsequently implant release factors that regulate endometrial epithelial cell gene expression and adhesion to facilitate endometrial receptivity? SUMMARY ANSWER: Blastocysts which subsequently implanted released factors that altered endometrial epithelial gene expression and facilitated endometrial adhesion while blastocysts that failed to implant did not. WHAT IS KNOWN ALREADY: Human preimplantation blastocysts are thought to interact with the endometrium to facilitate implantation. Very little is known of the mechanisms by which this occurs and to our knowledge there is no information on whether human blastocysts facilitate blastocyst attachment ..

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Awarded by Monash IVF (Australia)

Awarded by NHMRC

Funding Acknowledgements

We acknowledge the support of the Victorian Government's Operational Infrastructure Support Program and the Australian Government NHMRC IRIISS. We are very grateful to Dianne Arnold for assistance with the preparation of the manuscript.This work was supported by fellowships from the National Health and Medical Research Council (NHMRC) (Australia) and project grants by Monash IVF (Australia) (Grant #P2-FY13). E. D. was supported by NHMRC Senior Research Fellowship (#550905). E. M. was supported by NHMRC Early Career Fellowship (#611827) PHI Data Audit 12-24.