Journal article

Variability of outcome measures in trials of intravenous therapy in acute severe paediatric asthma: a systematic review

Charmaine S Gray, Colin VE Powell, Franz E Babl, Stuart R Dalziel, Simon Craig

EMERGENCY MEDICINE JOURNAL | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVE: To determine the variability of primary and secondary outcomes used in trials of intravenous bronchodilators in children with acute severe paediatric asthma. METHODS: Systematic search of MEDLINE, EMBASE, Cochrane CENTRAL and the WHO International Clinical Trials Registry Platform for randomised trials in children (less than18 years) with acute severe paediatric asthma comparing intravenous bronchodilator therapy to another treatment. Initial search was performed on 7 January 2016 with an updated search performed on 6 September 2018. Primary and secondary outcomes were collated. RESULTS: We identified 35 published papers and four registered study protocols. 56 primary outcomes wer..

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Grants

Awarded by National Health and Medical Research Council Centre of Research Excellence grant for paediatric emergency medicine


Awarded by Health Research Council of New Zealand


Funding Acknowledgements

FEB has been supported by a practitioner fellowship grant from the National Health and Medical Research Foundation, Canberra, Australia, and the Melbourne Children's Campus Clinician Scientist Fellowship, Parkville, Australia. SRD's time was part funded by the Health Research Council of New Zealand (HRC13/556). This research was supported by a National Health and Medical Research Council Centre of Research Excellence grant for paediatric emergency medicine (GNT1058560).