Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang; Jan Kudlacek; Jaroslav Hlinka; Jan Chvojka; Michal Hadrava; Vojtech Kumpost; Andrew D Powell; Radek Janca; Matias I Maturana; Philippa J Karoly; Dean R Freestone; Mark J Cook; Milan Palus; Jakub Otahal; John GR Jefferys; Premysl Jiruska

Journal article

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D Powell, Radek Janca, Matias I Maturana, Philippa J Karoly, Dean R Freestone, Mark J Cook, Milan Palus, Jakub Otahal, John GR Jefferys, Premysl Jiruska

Nature Neuroscience | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41593-018-0278-y

University of Melbourne Researchers

Matias Maturana Author Medicine - St Vincent's Hospital

Philippa Karoly Author Biomedical Engineering

Mark Cook Author Medicine - St Vincent's Hospital

Dean Freestone Author Medicine - St Vincent's Hospital

Grants

Awarded by Czech Science Foundation

Awarded by Ministry of Health of the Czech Republic

Awarded by Medical Research Council

Awarded by James Lewis Foundation through Epilepsy Research UK

Funding Acknowledgements

This study was supported by grants of the Czech Science Foundation GACR 14-02634S (to P.J.), Neuron Fund for Support of Science (to P.J.), the Ministry of Health of the Czech Republic AZV 15-29835A (to P.J.), 17-28427A (to P.J.), the Medical Research Council G0802162 (to J.G.R.J.), and the James Lewis Foundation through Epilepsy Research UK P1402 (to J.G.R.J.).