Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus
Josiane Fakhry, Martin J Stebbing, Billie Hunne, Yulia Bayguinov, Sean M Ward, Kent C Sasse, Brid Callaghan, Rachel M McQuade, John B Furness
CELL AND TISSUE RESEARCH | SPRINGER | Published : 2019
Gastric endocrine cell hormones contribute to the control of the stomach and to signalling to the brain. In other gut regions, enteroendocrine cells (EECs) exhibit extensive patterns of colocalisation of hormones. In the current study, we characterise EECs in the human gastric fundus and corpus. We utilise immunohistochemistry to investigate EECs with antibodies to ghrelin, serotonin (5-HT), somatostatin, peptide YY (PYY), glucagon-like peptide 1, calbindin, gastrin and pancreastatin, the latter as a marker of enterochromaffin-like (ECL) cells. EECs were mainly located in regions of the gastric glands populated by parietal cells. Gastrin cells were absent and PYY cells were very rare. Except..View full abstract
Awarded by NIH (SPARC) grant
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
This work was supported by NIH (SPARC) grant ID no. OT2OD023847 (PI Terry Powley) to JBF. SMW was supported by NIH DK57236.