Journal article

Latent Psychotic Symptom Profiles Amongst People Who Use Methamphetamine: What Do They Tell Us About Existing Diagnostic Categories?

Rebecca McKetin, Alexandra Voce, Richard Burns, Robert Ali, Dan I Lubman, Amanda L Baker, David J Castle

Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2018


The inability to distinguish clearly between methamphetamine-related psychosis and schizophrenia has led to the suggestion that "methamphetamine psychosis" does not represent a distinct diagnostic entity but rather that the drug has triggered a vulnerability to schizophrenia. We tested this possibility by exploring the latent class structure of psychotic symptoms amongst people who use the drug and examining how these latent symptom profiles correspond to a diagnosis of schizophrenia. Latent class analysis was carried out on the lifetime psychotic symptoms of 554 current methamphetamine users, of whom 40 met the DSM-IV criteria for schizophrenia. Lifetime diagnoses of schizophrenia and indiv..

View full abstract

University of Melbourne Researchers


Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

MATES was funded by the Australian National Health and Medical Research Council (Project Grant No. 350974) and the Australian Government Department of Health and Aging, was conducted by the National Drug and Alcohol Research Centre at the University of New South Wales, with contributions from other project investigators (Joanne Ross, Jake Najman, RA, Sharon Dawe, and Nicole Lee), research staff (Shelley Cogger, Erin Kelly, Kate Hetherington, Grace Ho, Cathie Sammut, Sagari Sarkar, Rachel Sutherland, Miriam Wyzenbeek, and Julia Rosenfeld), participating treatment agencies and participants. Other data collection was funded by ACT Health.