Exposure to General Anesthesia and Risk of Dementia: A Nationwide Population-Based Cohort Study
Clara Tammy Kim, Woojae Myung, Matthew Lewis, Hyewon Lee, Satbyul Estella Kim, Kyungsang Lee, Chunsoo Lee, Junbae Choi, Ho Kim, Bernard J Carroll, Doh Kwan Kim
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2018
BACKGROUND: There is a growing concern that general anesthesia could increase the risk of dementia. However, the relationship between anesthesia and subsequent dementia is still undetermined. OBJECTIVE: To determine whether the risk of dementia increases after exposure to general anesthesia. METHODS: A population-based prospective cohort study analyzing the Korean National Health Insurance Service-National Sample Cohort database was conducted of all persons aged over 50 years (n = 219,423) from 1 January 2003 and 31 December 2013. RESULTS: 44,956 in the general anesthesia group and 174,469 in the control group were followed for 12 years. The risk of dementia associated with previous exposure..View full abstract
Awarded by Global Research Lab through the National Research Foundation of Korea - Ministry of Science, ICT and future planning
Awarded by National Research Foundation of Korea - Korean Government
The ethics review board of Samsung Medical Center approved our access to anonymized data sets for these analyses. This research was supported by the Global Research Lab (#K21004000001-10A0500-00710; H Kim) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and future planning, and this work was also supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2017R1A2A1A17069653; DK Kim, NRF-2017R1D1A1B03029342 and NRF2018R1C1B6001708; W Myung, NRF-2012S1A6A3A01033504; Clara T Kim). This study was also funded by Eisai Inc. The funding source was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.