Journal article
Pneumococcal carriage in vaccine-eligible children and unvaccinated infants in Lao PDR two years following the introduction of the 13-valent pneumococcal conjugate vaccine
C Satzke, EM Dunne, M Choummanivong, BD Ortika, EFG Neal, CL Pell, ML Nation, KK Fox, CD Nguyen, KA Gould, J Hinds, A Chanthongthip, A Xeuatvongsa, EK Mulholland, V Sychareun, FM Russell
Vaccine | ELSEVIER SCI LTD | Published : 2019
Abstract
Pneumococcal carriage is a prerequisite for disease, and underpins herd protection provided by pneumococcal conjugate vaccines (PCVs). There are few data on the impact of PCVs in lower income settings, particularly in Asia. In 2013, the Lao People's Democratic Republic (Lao PDR) introduced 13-valent PCV (PCV13) as a 3 + 0 schedule (doses at 6, 10 and 14 weeks of age) with limited catch-up vaccination. We conducted two cross-sectional carriage surveys (pre- and two years post-PCV) to assess the impact of PCV13 on nasopharyngeal pneumococcal carriage in 5–8 week old infants (n = 1000) and 12–23 month old children (n = 1010). Pneumococci were detected by quantitative real-time PCR, and molecula..
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Awarded by Ministerio de Sanidad, Consumo y Bienestar Social
Funding Acknowledgements
The project was funded by Gavi, the Vaccine Alliance, and the World Health Organization Western Pacific Regional Office, with support from the Victorian Government's Operational Infrastructure Support Program. FR was supported by a NHMRC Early Career and TRIP Fellowships. CS was supported by a NHMRC Career Development Fellowship (1087957) and a veski Inspiring Women Fellowship. EFGN holds an Australian Government Research Training Scholarship. We thank Chansay Pathammvong and Phounphenghack Kongxay (Ministry of Health, Lao PDR); Alejandro Ramirez-Gonzalez and Rita Reyburn (World Health Organization); Jana Lai, Kathryn Bright and Kathryn Stanhope (MCRI).