Fracture Risk in Women with Dysglycaemia: Assessing Effects of Baseline and Time-Varying Risk Factors
Lelia LF de Abreu, Kara L Holloway-Kew, Mohammadreza Mohebbi, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco
CALCIFIED TISSUE INTERNATIONAL | SPRINGER | Published : 2019
Although individuals with diabetes appear to have a higher fracture risk compared to those without diabetes, fracture risk in impaired fasting glucose (IFG) has not been thoroughly explored. This study determined associations between glycaemia status and fracture risk. Women (n = 575, aged 50 + years) enrolled in the Geelong Osteoporosis Study, were followed from baseline (1993-1997), to date of first fracture, death or December 31, 2010, whichever occurred first (median 13.7 years, IQR 7.4-14.8). Hazard ratios (HRs) for any fracture (excluding fingers, toes, skull/face), as well as major osteoporotic fracture (MOF, clinical spine, hip, proximal humerus, wrist), in diabetes (n = 69), IFG (n ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC), Australia
The authors would like to acknowledge Dr Adrienne O'Neil for her role in obtaining the lipid levels in sera, Associate Professor Paul Lewandanski and his laboratory for performing the lipid analyses and the Australian Institute for Health and Welfare (AIHW) for death data. The Geelong Osteoporosis Study was supported by the Victorian Health Promotion Foundation, National Health and Medical Research Council (NHMRC), Australia (Projects 251638 and 628582), the Geelong Regional Medical Foundation; however, the funding bodies played no part in either the design or conduct of the study, the collection, management, analysis and interpretation of the data or the preparation or review of the paper. LFFA and MAS are supported by Postgraduate Scholarships from Deakin University. KLH-K is supported by an Alfred Deakin Postdoctoral Research Fellowship.