Journal article
Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma
MM Papamichael, C Katsardis, B Erbas, C Itsiopoulos, D Tsoukalas
Nutrition Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Abstract
Childhood asthma prevalence continues to rise despite advancements in prevention and medical management strategies. The purpose of this study was to investigate correlations between urinary organic acids and pulmonary diagnostic tests, asthma control in Greek asthmatic children. We hypothesized that urinary organic acids are positively associated with poor pulmonary function in children with asthma. Seventy-two children, 5 to 12 years old with asthma were recruited from a pediatric asthma clinic in Athens, Greece. Pulmonary function was assessed using spirometry and exhaled nitric oxide analysis. Asthma control was measured qualitatively using the Asthma Control Questionnaire. Targeted metab..
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Funding Acknowledgements
We gratefully acknowledge Basilopoulos and Sklavenitis supermarkets for their support to economically-disadvantaged families. The authors report no conflict of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The first author is supported by an Australian Post Graduate Award PhD Scholarship administered by La Trobe University. All co-authors declare that we have seen and approved the final version of the manuscript being submitted. The authors confirm that the article is the authors' original work, hasn't received prior publication and isn't under consideration for publication elsewhere. MP has devised the protocol, study design and is the principal author of the paper. CI is the principal investigator and DT, CK, BE and MP co-investigators. BE, CI, and DT contributed in drafting and in revision of the final article. BE guided analysis and interpretation of data.