Regular Alcohol Consumption Is Associated With Impaired Atrial Mechanical Function in the Atrial Fibrillation Population A Cross-Sectional MRI-Based Study
Aleksandr Voskoboinik, Benedict T Costello, Elana Kalman, Sandeep Prabhu, Hariharan Sugumar, Geoff Wong, Chrishan Nalliah, Liang-Han Ling, Alex McLellan, Thushan Hettige, Fabian Springer, Andre La Gerche, Jonathan M Kalman, Andrew J Taylor, Peter M Kistler
JACC Clinical Electrophysiology | ELSEVIER | Published : 2018
OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function. BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation. METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 stan..View full abstract
This research is supported in part by the Victorian Government's Operational Infrastructure Funding. Dr. Voskoboinik is supported by co-funded National Health and Medical Research Council (NHMRC)/National Heart Foundation (NHF) post-graduate scholarships and Baker Institute Bright Sparks scholarships. Dr. Jonathan Kalman is supported by an NHMRC practitioner fellowship. Dr. Prabhu has received fellowship support from Abbott and Boston Scientific. Dr. Sugumar is supported by an NHMRC/NHF post-graduate scholarship; and by the Cardiac Society of Australia and New Zealand. Dr. McLellan is supported by a Heart Foundation post-doctoral fellowship. Dr. La Gerche is supported by an NHMRC/NHF Future Leader Fellowship. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Michael R. Gold, MD, served as Guest Editor for this paper.