Metabolic-inflammatory status as predictor of clinical outcome at 1-year follow-up in patients with first episode psychosis.
Maria Antonietta Nettis, Giulio Pergola, Anna Kolliakou, Jennifer O'Connor, Stefania Bonaccorso, Anthony David, Fiona Gaughran, Marta Di Forti, Robin M Murray, Tiago Reis Marques, Giuseppe Blasi, Alessandro Bertolino, Carmine M Pariante, Paola Dazzan, Valeria Mondelli
Psychoneuroendocrinology | Published : 2019
BACKGROUND: Metabolic abnormalities and peripheral inflammation have been increasingly reported in patients at the onset of psychosis and associated with important physical health disorders and increased mortality. However, the impact of an abnormal metabolic-inflammatory status on the psychiatric outcome of these patients has not yet been investigated. OBJECTIVES: The aims of this study were 1) to explore whether, in a sample of patients at their first episode of psychosis (FEP), an overall metabolic-inflammatory status may be measured, by combining metabolic and inflammatory variables in metabolic-inflammatory factors; 2) to explore the association between these factors and clinical outcom..View full abstract
Awarded by Medical Research Council