Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial.
Sagnik Bhattacharyya, Robin Wilson, Elizabeth Appiah-Kusi, Aisling O'Neill, Michael Brammer, Jesus Perez, Robin Murray, Paul Allen, Matthijs G Bossong, Philip McGuire
JAMA Psychiatry | Published : 2018
Importance: Cannabidiol (CBD) has antipsychotic effects in humans, but how these are mediated in the brain remains unclear. Objective: To investigate the neurocognitive mechanisms that underlie the therapeutic effects of CBD in psychosis. Design, Setting, and Participants: In this parallel-group, double-blind, placebo-controlled randomized clinical trial conducted at the South London and Maudsley NHS Foundation Trust in London, United Kingdom, 33 antipsychotic medication-naive participants at clinical high risk (CHR) of psychosis and 19 healthy control participants were studied. Data were collected from July 2013 to October 2016 and analyzed from November 2016 to October 2017. Interventions:..View full abstract
Awarded by Medical Research Council
Awarded by Department of Health