Does environmental confounding mask pleiotropic effects of a multiple sclerosis susceptibility variant on vitamin D in psychosis?
Conrad O Iyegbe, Anita Acharya, John Lally, Poonam Gardner-Sood, Louise S Smith, Shubulade Smith, Robin Murray, Oliver Howes, Fiona Gaughran
npj Schizophrenia | Published : 2015
BACKGROUND: This work addresses the existing and emerging evidence of overlap within the environmental and genetic profiles of multiple sclerosis (MS) and schizophrenia. AIMS: To investigate whether a genetic risk factor for MS (rs703842), whose variation is indicative of vitamin D status in the disorder, could also be a determinant of vitamin D status in chronic psychosis patients. METHODS: A cohort of 224 chronic psychosis cases was phenotyped and biologically profiled. The relationship between rs703842 and physiological vitamin D status in the blood plasma was assessed by logistic regression. Deficiency was defined as a blood plasma concentration below 10 ng/µl. Potential environmental co..View full abstract
Awarded by Medical Research Council