Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study.
John Lally, Olesya Ajnakina, Nidhita Singh, Poonam Gardner-Sood, Brendon Stubbs, Dominic Stringer, Marta Di Forti, Anthony S David, Shubulade Smith, Robin M Murray, Oliver D Howes, Fiona Gaughran
Schizophr Res | Published : 2019
BACKGROUND: There is a paucity of longitudinal research investigating vitamin D in people with early psychosis. METHOD: Vitamin D levels were measured in 168 patients (64% (n = 108) male, mean age 29.3 (9.8) years) with first episode psychosis (FEP), along with measures of clinical state at baseline and at 12 months follow up. We assessed the a) cross sectional, and; b) longitudinal relationships between continuous and categorical 25-hydroxyvitamin D (25(OH)D) levels and clinical symptoms at first contact for psychosis and at 12 months. RESULTS: In FEP, 80% (n = 134) at baseline, and 76% at 12 months follow up, had suboptimal vitamin D levels (<20 ng/ml). Suboptimal levels of 25 (OH) D at ba..View full abstract
Awarded by Department of Health
Awarded by Medical Research Council