Journal article
Supragingival plaque microbiome ecology and functional potential in the context of health and disease
JL Espinoza, DM Harkins, M Torralba, A Gomez, SK Highlander, MB Jones, P Leong, R Saffery, M Bockmann, C Kuelbs, JM Inman, T Hughes, JM Craig, KE Nelson, CL Dupont
Mbio | AMER SOC MICROBIOLOGY | Published : 2018
Abstract
To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we constructed a genome encyclopedia describing the core supragingival plaque microbiome. Caries phenotypes contained statistically significant enrichments in specific genome abundances and distinct community composition profiles, including strain-level changes. Metabolic pathways that are statistically associated with caries include several sugar-associated phosphotransferase systems, antimicrobial resistance, and metal transport. Numerous closely related prev..
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Awarded by Financial Markets Foundation for Children
Funding Acknowledgements
The research in this publication was supported by the National Institute of Dental and Craniofacial Research of the National Institutes of Health under award number R01DE019665. PETS was supported by grants from the Australian National Health and Medical Research Council (grant numbers 437015 and 607358 to J.M.C. and R.S.), the Bonnie Babes Foundation (grant number BBF20704 to J.M.C.), the Financial Markets Foundation for Children (grant no. 032-2007 to J.M.C.), and the Victorian Government's Operational Infrastructure Support Program. CBRG was supported by grants from the Australian National Health and Medical Research Council (grant numbers 349448 and 1006294 to T.H.) and the Financial Markets Foundation for Children (grant no. 223-2009 to T.H.).