Journal article
Cost-effectiveness of procalcitonin testing to guide antibiotic treatment duration in critically ill patients: Results from a randomised controlled multicentre trial in the Netherlands
MMA Kip, JA Van Oers, A Shajiei, A Beishuizen, AMS Berghuis, AR Girbes, E De Jong, DW De Lange, MWN Nijsten, MJ Ijzerman, H Koffijberg, R Kusters
Critical Care | BMC | Published : 2018
Abstract
Background: Procalcitonin (PCT) testing can help in safely reducing antibiotic treatment duration in intensive care patients with sepsis. However, the cost-effectiveness of such PCT guidance is not yet known. Methods: A trial-based analysis was performed to estimate the cost-effectiveness of PCT guidance compared with standard of care (without PCT guidance). Patient-level data were used from the SAPS trial in which 1546 patients were randomised. This trial was performed in the Netherlands, which is a country with, on average, low antibiotic use and a short duration of hospital stay. As quality of life among sepsis survivors was not measured during the SAPS, this was derived from a Dutch foll..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
DWL reports grants from Thermo Fisher during the conduct of the SAPS-trial from which data has been used for this study. All other authors declare no competing interests related to this manuscript.