Journal article

The E3 ligase MARCH5 is a PPAR gamma target gene that regulates mitochondria and metabolism in adipocytes

Simon T Bond, Sarah C Moody, Yingying Liu, Mete Civelek, Claudio J Villanueva, Paul Gregorevic, Bronwyn A Kingwell, Andrea L Hevener, Aldons J Lusis, Darren C Henstridge, Anna C Calkin, Brian G Drew

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | AMER PHYSIOLOGICAL SOC | Published : 2019

Abstract

Mitochondrial dynamics refers to the constant remodeling of mitochondrial populations by multiple cellular pathways that help maintain mitochondrial health and function. Disruptions in mitochondrial dynamics often lead to mitochondrial dysfunction, which is frequently associated with disease in rodents and humans. Consistent with this, obesity is associated with reduced mitochondrial function in white adipose tissue, partly via alterations in mitochondrial dynamics. Several proteins, including the E3 ubiquitin ligase membrane-associated RING-CH-type finger 5 (MARCH5), are known to regulate mitochondrial dynamics; however, the role of these proteins in adipocytes has been poorly studied. Here..

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Grants

Awarded by National Heart, Lung, and Blood Institute


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

Confocal imaging was supported by Monash Micro Imaging (Monash University). This study was supported by an award from the Victorian State Government Operational Infrastructure Support Program (to the Baker Heart and Diabetes Institute) and National Heart, Lung, and Blood Institute Grants HL-121172 and HL-28481 (to A. J. Lusis and M. Civelek). B. G. Drew and A. C. Calkin are supported by National Heart Foundation of Australia Future Leader Fellowships.