Toxoplasmosis: A pathway to neuropsychiatric disorders
Shiraz Tyebji, Simona Seizova, Anthony J Hannan, Christopher J Tonkin
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the human central nervous system. Infection with Toxoplasma drastically alters the behaviour of rodents and is associated with the incidence of specific neuropsychiatric conditions in humans. But the question remains: how does this pervasive human pathogen alter behaviour of the mammalian host? This fundamental question is receiving increasing attention as it has far reaching public health implications for a parasite that is very common in human populations. Our current understanding centres on neuronal changes that are elicited directly by this intracellular parasite versus indirect changes that occur..View full abstract
We would like to thank members of the Tonkin Laboratory for helpful discussions that has contributed towards the preparation of this manuscript. The research in this laboratory is supported by The David Winston Turner Foundation, Melbourne. AJH is an NHMRC Principal Research Fellow.