Journal article
Changes in Body Mass Index and Rates of Death and Transplant in Hemodialysis Patients A Latent Class Joint Modeling Approach
Samuel L Brilleman, Margarita Moreno-Betancur, Kevan R Polkinghorne, Stephen P McDonald, Michael J Crowther, Jim Thomson, Rory Wolfe
EPIDEMIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
BACKGROUND: The relationship between body mass index (BMI) and patient survival in end-stage kidney disease is not well understood and has been the subject of much debate over recent years. METHODS: This study used a latent class joint modeling approach to identify latent groups that underpinned associations between patterns of change in BMI during hemodialysis and two competing events: transplant and death without transplant. We included all adult patients who initiated chronic hemodialysis treatment in Australia or New Zealand between 2005 and 2014. RESULTS: There were 16,414 patients included in the analyses; 2,365 (14%) received a transplant, 5,639 (34%) died before transplant, and 8,410..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Centre of Research Excellence grant
Awarded by UK Medical Research Council (MRC) New Investigator Research Grant
Awarded by MRC
Funding Acknowledgements
S.L.B. is funded by an Australian National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (ref: APP1093145), with additional support from an NHMRC Centre of Research Excellence grant (ref: 1035261) awarded to the Victorian Centre for Biostatistics (ViCBiostat). M.J.C. is partly funded by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P015433/1). The ANZDATA Registry is funded by the Australian Organ and Tissue Donation and Transplantation Authority, the New Zealand Ministry of Health and Kidney Health Australia.