Journal article

Changes in Body Mass Index and Rates of Death and Transplant in Hemodialysis Patients A Latent Class Joint Modeling Approach

Samuel L Brilleman, Margarita Moreno-Betancur, Kevan R Polkinghorne, Stephen P McDonald, Michael J Crowther, Jim Thomson, Rory Wolfe

EPIDEMIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

BACKGROUND: The relationship between body mass index (BMI) and patient survival in end-stage kidney disease is not well understood and has been the subject of much debate over recent years. METHODS: This study used a latent class joint modeling approach to identify latent groups that underpinned associations between patterns of change in BMI during hemodialysis and two competing events: transplant and death without transplant. We included all adult patients who initiated chronic hemodialysis treatment in Australia or New Zealand between 2005 and 2014. RESULTS: There were 16,414 patients included in the analyses; 2,365 (14%) received a transplant, 5,639 (34%) died before transplant, and 8,410..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Centre of Research Excellence grant


Awarded by UK Medical Research Council (MRC) New Investigator Research Grant


Awarded by MRC


Funding Acknowledgements

S.L.B. is funded by an Australian National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (ref: APP1093145), with additional support from an NHMRC Centre of Research Excellence grant (ref: 1035261) awarded to the Victorian Centre for Biostatistics (ViCBiostat). M.J.C. is partly funded by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P015433/1). The ANZDATA Registry is funded by the Australian Organ and Tissue Donation and Transplantation Authority, the New Zealand Ministry of Health and Kidney Health Australia.