Journal article

Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH

Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri

ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2018

Abstract

Nanostructured materials have potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesis of electrocatalytically active cobalt phosphate nanostructures (CPNs) using a simple, low-cost, and scalable preparation method. The electrocatalytic properties of CPNs toward the electrooxidation of glucose (Glu) were studied by cyclic voltammetry and chronoamperometry in relevant biological electrolytes, such as phosphate-buffered saline (PBS), at physiological pH (7.4). Using CPNs, Glu detection could be achieved over a wide range of biologically relevant concentrations, from 1 to 30 mM Glu in PBS, with a sensitivity of 7.90 nA/mM cm2 and a limit of detection..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council Fellowship


Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology


Funding Acknowledgements

This work was supported by the Australian Research Council (ARC) under a Future Fellowship (F. Cavalieri, FT140100873) and a National Health and Medical Research Council Fellowship (F. Caruso, APP1135806). This research was conducted and supported by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by a University of Melbourne Establishment Grant (F. Cavaliers).