Journal article

Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2019


BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophrenia, these relationships are not apparent in healthy individuals. Further, few studies have examined the role of hippocampal subfields in illness-related memory deficits, and no study has examined potential differences across varying illness stages. The current study aimed to investigate whether individuals with early and established psychosis exhibited differential relationships between visuospatial associative memory and hippocampal subfield volumes. METHODS: Measurements of visuospatial associative memory performance and grey matter volume were obtained from 52 ..

View full abstract


Awarded by NHMRC

Awarded by Brain and Behavior Research Foundation (NARSAD) Young Investigator Award

Awarded by National Health and Medical Research Council (NHMRC) Early Career Fellowship

Funding Acknowledgements

The authors acknowledge the financial support of the CRC for Mental Health. The Cooperative Research Centre (CRC) programme is an Australian Government Initiative. The authors also wish to acknowledge the CRC Scientific Advisory Committee, in addition to the contributions of study participants, clinicians at recruitment services, staff at the Murdoch Children's Research Institute, staff at the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging, and research staff at the Melbourne Neuropsychiatry Centre, including coordinators Phassouliotis, C., Merritt, A., and research assistants, Burnside, A., Cross, H., Gale, S., and Tahtalian, S. We would also like to thank Chester Kang for IT support. CW was supported by a CRC for Mental Health Ph.D. top-up scholarship. The CAB was supported by NHMRC Career Development Fellowship (1127700) and Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (20526). CP was supported by NHMRC Senior Principal Research Fellowship (628386 & 1105825). TVR was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (1088785). All authors have no biomedical financial interests or conflicts of interest to declare. None of the funding sources played any role in the study design; collection, analysis or interpretation of data, in the writing of the manuscript; or in the decision to submit the manuscript for publication.