Characterising Arm Recovery in People with Severe Stroke (CARPSS): protocol for a 12-month observational study of clinical, neuroimaging and neurophysiological biomarkers
Kathryn S Hayward, Keith R Lohse, Julie Bernhardt, Catherine E Lang, Lara A Boyd
BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2018
INTRODUCTION: In individuals with early (indexed ≤7 days poststroke) and severe upper limb paresis (shoulder abduction and finger extension score of <5 out of 10), our objectives are to: (1) determine if biomarkers of brain structure and function collected at <1 month poststroke explain who will experience clinically important recovery over the first 12 months poststroke; (2) compare stroke survivors' perceptions of personally meaningful recovery to clinically important recovery; and (3) characterise the trajectory of change in measures of motor function, brain structure and function. METHODS AND ANALYSIS: Prospective observational study with an inception cohort of 78 first-time stroke survi..View full abstract
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Awarded by Canadian Institutes of Health Research (CIHR)
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
This work is supported by a Canadian Institutes of Health Research (CIHR) project grant (PJT-153330, 2017-2021) awarded to LAB, KSH, JB, CEL and KRL; and a Jakeway Foundation Grant for project start-up (2016) awarded to LAB and KSH.