Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons; Wen Shi Lee; Anne B Kristensen; Thakshila Amarasena; Georges Khoury; Adam K Wheatley; Arnold Reynaldi; Bruce D Wines; P Mark Hogarth; Miles P Davenport; Stephen J Kent

Journal article

Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Georges Khoury, Adam K Wheatley, Arnold Reynaldi, Bruce D Wines, P Mark Hogarth, Miles P Davenport, Stephen J Kent

Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2019

DOI: 10.1172/JCI122466

University of Melbourne Researchers

Matt Parsons Author Microbiology and Immunology

Adam Wheatley Author Microbiology and Immunology

Stephen Kent Author Microbiology and Immunology

Wen Shi Lee Author Microbiology and Immunology

Bruce Wines Author Clinical Pathology

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We acknowledge S. Alcantara, S. Pantham, A. Owen, M. Schepers, and C. McClumpha (all from The University of Melbourne) for expert assistance with animal care and sample processing. This work was funded by grants from the Australian National Health and Medical Research Council (NHMRC) (grants 1101813, 1124680, 1052979, and 1136322) and the Australian Centre for HIV and Hepatitis Virology Research (to SJK and/or MSP).