Is high vitamin B12 status a cause of lung cancer?

A Fanidi; R Carreras-Torres; TL Larose; JM Yuan; VL Stevens; SJ Weinstein; D Albanes; R Prentice; M Pettinger; Q Cai; WJ Blot; AA Arslan; A Zeleniuch-Jacquotte; ML McCullough; L Le Marchand; LR Wilkens; CA Haiman; X Zhang; MJ Stampfer; SA Smith-Warner; E Giovannucci; GG Giles; AM Hodge; G Severi; M Johansson; K Grankvist; A Langhammer; BM Brumpton; R Wang; YT Gao; U Ericson; SE Bojesen; SM Arnold; WP Koh; XO Shu; YB Xiang; H Li; W Zheng; Q Lan; K Visvanathan; J Hoffman-Bolton; PM Ueland; Ø Midttun; NE Caporaso; M Purdue; ND Freedman; JE Buring; IM Lee; HD Sesso; J Michael Gaziano; J Manjer; CL Relton; RJ Hung; CI Amos; M Johansson; P Brennan

Journal article

Is high vitamin B12 status a cause of lung cancer?

A Fanidi, R Carreras-Torres, TL Larose, JM Yuan, VL Stevens, SJ Weinstein, D Albanes, R Prentice, M Pettinger, Q Cai, WJ Blot, AA Arslan, A Zeleniuch-Jacquotte, ML McCullough, L Le Marchand, LR Wilkens, CA Haiman, X Zhang, MJ Stampfer, SA Smith-Warner Show all

International Journal of Cancer | Published : 2019

DOI: 10.1002/ijc.32033

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Abstract

Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre-diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre-diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms ass..

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