Journal article

Can youth at high risk of illness progression be identified by measures of rumination and sleep-wake disturbance

Ashlee B Grierson, Jan Scott, Nick Glozier, Ian B Hickie, Paul G Amminger, Eoin Killackey, Patrick D McGorry, Christos Pantelis, Lisa Phillips, Elizabeth Scott, Alison R Yung, Rosemary Purcell

Early Intervention in Psychiatry | WILEY | Published : 2019

Abstract

AIM: Clinical staging models offer a useful framework for understanding illness trajectories, where individuals are located on a continuum of illness progression from stage 0 (at-risk but asymptomatic) to stage 4 (end-stage disease). Importantly, clinical staging allows investigation of risk factors for illness progression with the potential to target trans-diagnostic mechanisms at an early stage, especially in help-seeking youth who often present with sub-threshold syndromes. While depressive symptoms, rumination and sleep-wake disturbances may worsen syndrome outcomes, the role of these related phenomena has yet to be examined as risk factors for trans-diagnostic illness progression in at-..

View full abstract

Grants

Awarded by NHMRC


Awarded by Research for Patient Benefit programme


Awarded by National Health and Medical Research Council


Funding Acknowledgements

NHMRC Program Grant, Grant/Award Number: 566529; Eli Lilly and Company; AstraZeneca; Pfizer; Servier; Research for Patient Benefit programme, Grant/Award Number: PB-PG-0609-16166; Medical Research Council; National Health and Medical Research Council, Grant/Award Number: ID: 566529