Journal article

Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds

Megan Heffernan, Gavin Andrews, Maria A Fiatarone Singh, Michael Valenzuela, Kaarin J Anstey, Anthony J Maeder, John McNeil, Louisa Jorm, Nicola T Lautenschlager, Perminder S Sachdev, Jeewani A Ginige, Megan J Hobbs, Christos Boulamatsis, Tiffany Chau, Lynne Cobiac, Kay L Cox, Kenneth Daniel, Victoria M Hood, Yareni Guerrero, Jane Gunn Show all

Journal of Alzheimer's Disease | IOS PRESS | Published : 2019


BACKGROUND: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. METHODS: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules..

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Awarded by National Health and Medical Research (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This trial was funded by a National Health and Medical Research (NHMRC) Dementia Research Team Grant (APP1095097). MV was supported by a NHMRC career development fellowship (APP1112813). Participants will be recruited from the 45 and Up Study ( The 45 and Up Study is managed by the Sax Institute in collaboration with major partner Cancer Council NSW; and partners: The National Heart Foundation of Australia (NSW Division); NSW Ministry of Health; NSW Government Family & Community Services - Ageing, Carers and the Disability Council NSW; and the Australian Red Cross Blood Service. We thank the many thousands of people participating in the 45 and Up Study. We acknowledge the contributions of the Maintain Your Brain Collaborative Team: Nan Bosler, Brigid Betz-Stablein, Nancy Briggs, Helen Christensen, Igor Chuprov, Andrew Hayen, Miia Kivipelto, Helen Lapsley, Sally Redman, Juan Carlo San Jose, and Heidi Welberry; and the MYB Data Safety Monitoring Board. MYB uses tasks developed by Cogstate Ltd, Cambridge Brain Sciences, and NeuroNation. MYB thanks Signs Publishing for a non-exclusive license to use traditional Mediterranean recipes from Food as Medicine: Cooking for Your Best Health by Sue Radd and Adventist Media Network for production and use of cooking videos.