Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307
Kelly L Wyres, Jane Hawkey, Marit AK Hetland, Aasmund Fostervold, Ryan R Wick, Louise M Judd, Mohammad Hamidian, Benjamin P Howden, Iren H Lohr, Kathryn E Holt
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2019
OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinan..View full abstract
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Awarded by NHMRC of Australia
Awarded by Western Norway Regional Health Authority
This work was supported by: the Viertel Foundation of Australia; the NHMRC of Australia (fellowship number GNT1105905 to B. P. H.); The Western Norway Regional Health Authority (fellowship numbers 912037, 912119 and grant number 912050); and the Bill and Melinda Gates Foundation, Seattle.