Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
Kevin Sek, Christina Molck, Gregory D Stewart, Lev Kats, Phillip K Darcy, Paul A Beavis
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2018
The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of 'checkpoint blockade' and adoptive cellular therapy has revolutionized the landscape of cancer treatment and highlights the potential of utilizing the patient's own immune system to eradicate cancer. One mechanism of tumor-mediated immunosuppression that has gained attention as a potential therapeutic target is the purinergic signaling axis, whereby the production of the purine nucleoside adenosine in the tumor microenvironment can potently suppress T and NK cel..View full abstract
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Awarded by National Breast Cancer Foundation Fellowship
Awarded by NHMRC Senior Research Fellowship
P.A.B. is supported by a National Breast Cancer Foundation Fellowship (ID#ECF-17-005). P.K.D. is supported by an NHMRC Senior Research Fellowship (APP1136680).