Journal article

Epigenomic drivers of immune dysfunction in aging

Christine R Keenan, Rhys S Allan

AGING CELL | WILEY | Published : 2019

Abstract

Aging inevitably leads to reduced immune function, leaving the elderly more susceptible to infections, less able to respond to pathogen challenges, and less responsive to preventative vaccinations. No cell type is exempt from the ravages of age, and extensive studies have found age-related alterations in the frequencies and functions of both stem and progenitor cells, as well as effector cells of both the innate and adaptive immune systems. The intrinsic functional reduction in immune competence is also associated with low-grade chronic inflammation, termed "inflamm-aging," which further perpetuates immune dysfunction. While many of these age-related cellular changes are well characterized, ..

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Grants

Awarded by NHMRC Early Career Fellowship


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

This work is supported by the National Health and Medical Research Council (NHMRC) of Australia. CRK is supported by an NHMRC Early Career Fellowship 1125436. RSA is supported by an Australian Research Council Future Fellowship 130100541.