Treatment of fecal impaction in children using combined polyethylene glycol and sodium picosulphate
Anthony Lamanna, Lauren D Dughetti, Julie A Jordan-Ely, Kyla M Dobson, Megan Dynan, Adeline Foo, Louise MP Kooiman, Naomi Murakami, Kaic Fiuza, Siavash Foroughi, Marcelo Leal, Suzanna Vidmar, Anthony G Catto-Smith, John M Hutson, Bridget R Southwell
JGH OPEN | WILEY | Published : 2018
Background and Aim: Polyethylene glycol (PEG) is the gold standard for fecal disimpaction in constipation. A regimen of PEG combined with the stimulant laxative sodium picosulphate (SPS) produced fecal disimpaction in chronically constipated children in the community, but it is unknown if it is effective for more severe constipation. To determine the stool output and effect of a combined PEG and SPS regimen on fecaloma in children with severe constipation and impaction. Methods: Children with symptoms for a duration of ≥2 years, a palpable fecaloma, and enlarged rectum on X-ray (rectal: pelvic ratio > 0.6) were recruited from a tertiary hospital. Daily diaries recorded laxative dose, stool f..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This study was funded by the Australian National Health and Medical Research Council (NHMRC), Project Grant (1025726) 2012-2016 and was supported by the "Victorian Government Operational Infrastructural Support Program" and the Senior Research Fellowship (BS, 607396). The trial was registered for clinical trial registration-ACTRN12612001009808. http://www.anzctr.org.au/TrialSearch.aspx? searchTxt=ACTRN12612001009808.&isBasic=True. The study was presented to the Gastroenterology Society of Australia Annual meeting (Australian Gastro Week) in August 2017 and published in the abstracts of the Journal of Gastroenterology and Hepatology Volume 32, Issue S2, August 2017, Pages: 190-197, Version of Record online: 17 August 2017, DOI: 10.1111/jgh. 13900. Data on symptom changes in subsets of the patients were presented at the American Gastroenterology Association Annual meeting (Digestive Diseases Week, 2015 (Southwell BR, Dughetti LD, Jordan-Ely JA, Dobson KM, Stathopolous L, Leal MC, et al. Su2051 Combined Polyethylene Glycol and Sodium Picosulphate for Disimpaction in Children With Chronic Constipation and Palpable Faecaloma. Gastroenterology 2015; 148 (4):S-585) and the Gastroenterology Society of Australia Annual Meeting (Australian Gastro Week) in 2016 (Jordan-Ely J, Dughetti L, Dobson K, Stathopoulos L, Lamanna A, Leal M, et al. Disimpaction for children with palpable faecalomas using polyethelene glycol and sodium picosulphate. J Gastroenterol Hepatol. 2016; 31:178-9).