Impact of Intrauterine Growth Restriction on the Capillarization of the Early Postnatal Rat Heart
Megan R Sutherland, Ka Wing Ng, Joerg D Drenckhahn, Mary E Wlodek, Mary Jane Black
The Anatomical Record | WILEY | Published : 2019
Capillarization plays a key role in the growth of the developing heart. We therefore hypothesized that impaired heart development following intrauterine growth restriction (IUGR) may arise from inadequate myocardial capillary growth. The aims of the study were to examine the effect of IUGR on the growth and diffusion radius of intramyocardial capillaries in rats at postnatal day 1. Uteroplacental insufficiency was induced in rats in late gestation (E18, term = E22) by bilateral uterine artery and vein ligation (restricted offspring N = 12; six males and six females); offspring from sham-operated dams were used as controls (N = 10; five males and five females). At postnatal day 1, the hearts ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Grant sponsor: National Health and Medical Research Council (NHMRC); Grant number: MEW: 208948 MRS: CJ Martin ECR Fellowship.