Journal article

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants

Sehee Kim, Miao Wang, Jonathan P Tyrer, Allan Jensen, Ashley Wiensch, Gang Liu, Alice W Lee, Roberta B Ness, Maxwell Salvatore, Shelley S Tworoger, Alice S Whittemore, Hoda Anton-Culver, Weiva Sieh, Sara H Olson, Andrew Berchuck, Ellen L Goode, Marc T Goodman, Jennifer Anne Doherty, Georgia Chenevix-Trench, Mary Anne Rossing Show all



As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs. never) and rs13255292 (p value = 3.48 × 10-4 ). Among women with the TT genotype for thi..

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Awarded by Ovarian Cancer Research Fund

Awarded by German Federal Ministry of Education and Research

Awarded by Kraeftens Bekaempelse

Awarded by Lon V Smith Foundation

Awarded by Medical Research and Materiel Command

Awarded by National Cancer Institute

Awarded by National Cancer Institute's Genetic Associations and Mechanisms in Oncology

Awarded by National Center for Research Resources

Awarded by National Health and Medical Research Council

Awarded by National Health Research and Development Program, Health Canada

Awarded by National Institute of Environmental Health Sciences

Awarded by National Institutes of Health

Awarded by National Science Foundation

Awarded by Seventh Framework Programme

Awarded by U.S. Department of Defense



Funding Acknowledgements

Cancer Institute of New Jersey; Grant sponsor: Ovarian Cancer Research Fund; Grant number: PPD/RPCI. 074; Grant sponsor: Deutsches Krebsforschungszentrum; Grant sponsor: Fred C. and Katherine B. Andersen Foundation; Grant sponsor: German Federal Ministry of Education and Research; Grant number: 01 GB 9401; Grant sponsor: Intramural Research Program of the National Cancer Institute; Grant sponsor: Kraeftens Bekaempelse; Grant number: 94 222 52; Grant sponsor: Lon V Smith Foundation; Grant number: LVS-39420; Grant sponsor: Mayo Foundation; Grant sponsor: Medical Research and Materiel Command; Grant number: DAMD17-01-1-0729; Grant sponsor: Mermaid I project; Grant sponsor: Minnesota Ovarian Cancer Alliance; Grant sponsor: National Cancer Institute; Grant numbers: 1 R01CA160669-01A1, K07-CA080668, NIH-K07 CA095666, NIH-K22-CA138563, P30 CA04, P30 CA046592, P30-CA008748, P30-CA072720, P50-CA159981, R01 CA076016, R01-CA61107, R01-CA83918, R01-CA95023, R21-CA222867; Grant sponsor: National Cancer Institute's Genetic Associations and Mechanisms in Oncology; Grant number: U19-CA148112; Grant sponsor: National Center for Research Resources; Grant number: M01-RR000056; Grant sponsor: National Health and Medical Research Council; Grant numbers: 1043134, 199600, ID400281, ID400413, 209057, 396414, 1074383; Grant sponsor: National Health Research and Development Program, Health Canada; Grant number: 6613-1415-53; Grant sponsor: National Institute for Health Research University College London Hospitals Biomedical Research Centre; Grant sponsor: National Institute of Environmental Health Sciences; Grant number: NIH ES 20811 BM; Grant sponsor: National Institutes of Health; Grant numbers: K22 CA193860, N01-CN-55424, N01-PC-67001, N01CN025403, N01PC67010, P01 CA87969, P01CA17054, P30-CA15083, P30CA14089, P50-CA105009, P50-CA136393, R01 CA49449, R01-CA0568860, R01-CA063678, R01 -CA074850, R01-CA080742, R01-CA112523, R01-CA122443, R01-CA54419, R01-CA58598, R01-CA67262, R01-CA76016, R01-CA87538, R01 CA61132, R03CA113148, R03CA115195, T32 ES013678, U01 CA69417, U01 CA71966, UM1 CA176726, UM1 CA186107; Grant sponsor: National Science Foundation; Grant number: NSF DMS 1406712 BM; Grant sponsor: Ovarian Cancer Australia; Grant sponsor: Peter MacCallum Foundation; Grant sponsor: Seventh Framework Programme; Grant number: 223175 HEALTH F2 2009-223175; Grant sponsor: The Eve Appeal (The Oak Foundation); Grant sponsor: U.S. Department of Defense; Grant numbers: DAMD17-02-1-0666DAMD17-02-1-0669W81XWH-10-1-02802; Grant sponsor: Connecticut Department of Public Health; Grant sponsor: State of Connecticut Department of Public Health