Journal article
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome
HA Yoon, A Nakouzi, CC Chang, MH Kuniholm, LJ Carreño, T Wang, T Ndung'u, SR Lewin, MA French, LA Pirofski
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2019
Abstract
Background. Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected individuals with cryptococcal meningitis places them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The relationship between antibody immunity and C-IRIS risk has not been investigated. Methods. We compared plasma levels of immunoglobulins, C. neoformans glucuronoxylomannan (GXM) capsule-specific and laminarin (Lam)-binding IgM and IgG, and percentages of peripheral blood total and memory B cells between 27 HIV-infected patients with CM who developed C-IRIS and 63 who did not, and evaluated associations of these parameters with risk of C-IRIS. Resul..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Institutes of Health (grant number R01 AI 097096 to L. P.); Australian National Health and Medical Research Council Early Career Fellowship (grant number APP1092160 to C. C. C) and Practitioner Fellowship to S. R. L.; Howard Hughes Medical Institute International Early Career Scientist Award to T. N.; Wellcome Trust through the Sub-Saharan African Network for TB/HIV Research Excellence (grant number DEL-15-006 to T. N.); and the South African National Research Foundation Research Chairs Initiative to T. N.