Journal article

Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome

Hyun Ah Yoon, Antonio Nakouzi, Christina C Chang, Mark H Kuniholm, Leandro J Carreno, Tao Wang, Thumbi Ndung'u, Sharon R Lewin, Martyn A French, Liise-anne Pirofski

JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2019

Abstract

Background: Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected individuals with cryptococcal meningitis places them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The relationship between antibody immunity and C-IRIS risk has not been investigated. Methods: We compared plasma levels of immunoglobulins, C. neoformans glucuronoxylomannan (GXM) capsule-specific and laminarin (Lam)-binding IgM and IgG, and percentages of peripheral blood total and memory B cells between 27 HIV-infected patients with CM who developed C-IRIS and 63 who did not, and evaluated associations of these parameters with risk of C-IRIS. Resul..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by Australian National Health and Medical Research Council


Awarded by Wellcome Trust through the Sub-Saharan African Network for TB/HIV Research Excellence


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the National Institutes of Health (grant number R01 AI 097096 to L. P.); Australian National Health and Medical Research Council Early Career Fellowship (grant number APP1092160 to C. C. C) and Practitioner Fellowship to S. R. L.; Howard Hughes Medical Institute International Early Career Scientist Award to T. N.; Wellcome Trust through the Sub-Saharan African Network for TB/HIV Research Excellence (grant number DEL-15-006 to T. N.); and the South African National Research Foundation Research Chairs Initiative to T. N.