Journal article
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome
Hyun Ah Yoon, Antonio Nakouzi, Christina C Chang, Mark H Kuniholm, Leandro J Carreno, Tao Wang, Thumbi Ndung'u, Sharon R Lewin, Martyn A French, Liise-anne Pirofski
JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2019
Abstract
Background: Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected individuals with cryptococcal meningitis places them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The relationship between antibody immunity and C-IRIS risk has not been investigated. Methods: We compared plasma levels of immunoglobulins, C. neoformans glucuronoxylomannan (GXM) capsule-specific and laminarin (Lam)-binding IgM and IgG, and percentages of peripheral blood total and memory B cells between 27 HIV-infected patients with CM who developed C-IRIS and 63 who did not, and evaluated associations of these parameters with risk of C-IRIS. Resul..
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Awarded by National Institutes of Health
Awarded by Australian National Health and Medical Research Council
Awarded by Wellcome Trust through the Sub-Saharan African Network for TB/HIV Research Excellence
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Funding Acknowledgements
This work was supported by the National Institutes of Health (grant number R01 AI 097096 to L. P.); Australian National Health and Medical Research Council Early Career Fellowship (grant number APP1092160 to C. C. C) and Practitioner Fellowship to S. R. L.; Howard Hughes Medical Institute International Early Career Scientist Award to T. N.; Wellcome Trust through the Sub-Saharan African Network for TB/HIV Research Excellence (grant number DEL-15-006 to T. N.); and the South African National Research Foundation Research Chairs Initiative to T. N.