Journal article

Valproic acid attenuates hyperglycemia-induced complement and coagulation cascade gene expression

Marina Barreto Felisbino, Mark Ziemann, Ishant Khurana, Camila Borges Martins de Oliveira, Maria Luiza Mello, Assam El-Osta, Assam El-Osta

Published : 2018

Abstract

ABSTRACT Atherothrombosis remains the leading cause of morbidity and mortality in patients diagnosed with diabetes mellitus, but the molecular mechanisms underpinning this remain unresolved. As the liver plays a major role in metabolic homeostasis and secretion of clotting factors and inflammatory innate immune proteins, there is an interest in understanding the mechanisms of hepatic cell activation under hyperglycemia and whether this can be attenuated pharmacologically. We have previously shown that hyperglycemia stimulates major changes in chromatin organisation and metabolism in hepatocytes, and that the histone deacetylase inhibitor valproic acid (VPA; IUPAC: 2-propylpentanoic acid) is ..

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University of Melbourne Researchers