Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem
Hyon-Xhi Tan, Sinthujan Jegaskanda, Jennifer A Juno, Robyn Esterbauer, Julius Wong, Hannah G Kelly, Yi Liu, Danielle Tilmanis, Aeron C Hurt, Jonathan W Yewdell, Stephen J Kent, Adam K Wheatley
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2019
Awarded by National Health and Medical Research Council (NHMRC) program
Awarded by NHMRC
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank the clinical trial staff and participants and Kathleen Wragg for technical support (Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity). This work was supported by National Health and Medical Research Council (NHMRC) program grant ID1052979 (to SJK) and NHMRC project grant ID1129099 (to AKW). YL and JW are supported by a Melbourne International Research Scholarship and a Melbourne International Fee Remission Scholarship. JAJ is supported by a NHMRC fellowship. The Melbourne WHO Collaborating Centre for Reference Research on Influenza is supported by the Australian Government Department of Health.