GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Nora Franceschini; Claudia Giambartolomei; Paul S de Vries; Chris Finan; Joshua C Bis; Rachael P Huntley; Ruth C Lovering; Salman M Tajuddin; Thomas W Winkler; Misa Graff; Maryam Kavousi; Caroline Dale; Albert V Smith; Edith Hofer; Elisabeth M van Leeuwen; Ilja M Nolte; Lingyi Lu; Markus Scholz; Muralidharan Sargurupremraj; Niina Pitkanen; Oscar Franzen; Peter K Joshi; Raymond Noordam; Riccardo E Marioni; Shih-Jen Hwang; Solomon K Musani; Ulf Schminke; Walter Palmas; Aaron Isaacs; Adolfo Correa; Alan B Zonderman; Albert Hofman; Alexander Teumer; Amanda J Cox; Andre G Uitterlinden; Andrew Wong; Andries J Smit; Anne B Newman; Annie Britton; Arno Ruusalepp; Bengt Sennblad; Bo Hedblad; Bogdan Pasaniuc; Brenda W Penninx; Carl D Langefeld; Christina L Wassel; Christophe Tzourio; Cristiano Fava; Damiano Baldassarre; Daniel H O'Leary; Daniel Teupser; Diana Kuh; Elena Tremoli; Elmo Mannarino; Enzo Grossi; Eric Boerwinkle; Eric E Schadt; Erik Ingelsson; Fabrizio Veglia; Fernando Rivadeneira; Frank Beutner; Ganesh Chauhan; Gerardo Heiss; Harold Snieder; Harry Campbell; Henry Voelzke; Hugh S Markus; Ian J Deary; J Wouter Jukema; Jacqueline de Graaf; Jacqueline Price; Janne Pott; Jemma C Hopewell; Jingjing Liang; Joachim Thiery; Jorgen Engmann; Karl Gertow; Kenneth Rice; Kent D Taylor; Klodian Dhana; Lambertus ALM Kiemeney; Lars Lind; Laura M Raffield; Lenore J Launer; Lesca M Holdt; Marcus Doer; Martin Dichgans; Matthew Traylor; Matthias Sitzer; Meena Kumari; Mika Kivimaki; Mike A Nalls; Olle Melander; Olli Raitakari; Oscar H Franco; Oscar L Rueda-Ochoa; Panos Roussos; Peter H Whincup; Philippe Amouyel; Philippe Giral; Pramod Anugu; Quenna Wong; Rainer Malik; Rainer Rauramaa; Ralph Burkhardt; Rebecca Hardy; Reinhold Schmidt; Renee de Mutsert; Richard W Morris; Rona J Strawbridge; S Goya Wannamethee; Sara Hagg; Sonia Shah; Stela McLachlan; Stella Trompet; Sudha Seshadri; Sudhir Kurl; Susan R Heckbert; Susan Ring; Tamara B Harris; Terho Lehtimaki; Tessel E Galesloot; Tina Shah; Ulf de Faire; Vincent Plagnol; Wayne D Rosamond; Wendy Post; Xiaofeng Zhu; Xiaoling Zhang; Xiuqing Guo; Yasaman Saba; Abbas Dehghan; Adrie Seldenrijk; Alanna C Morrison; Anders Hamsten; Bruce M Psaty; Cornelia M van Duijn; Deborah A Lawlor; Dennis O Mook-Kanamori; Donald W Bowden; Helena Schmidt; James F Wilson; James G Wilson; Jerome I Rotter; Joanna M Wardlaw; John Deanfield; Julian Halcox; Leo-Pekka Lyytikainen; Markus Loeffler; Michele K Evans; Stephanie Debette; Steve E Humphries; Uwe Voelker; Vilmundur Gudnason; Aroon D Hingorani; Johan LM Bjorkegren; Juan P Casas; Christopher J O'Donnell

Journal article

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Nora Franceschini, Claudia Giambartolomei, Paul S de Vries, Chris Finan, Joshua C Bis, Rachael P Huntley, Ruth C Lovering, Salman M Tajuddin, Thomas W Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V Smith, Edith Hofer, Elisabeth M van Leeuwen, Ilja M Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkanen Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41467-018-07340-5

Download PDF

University of Melbourne Researchers

Vincent Thijs Author Florey Department of Neuroscience and Mental Health

Grants

Awarded by National Institute of Health

Awarded by National Institutes of Health

Awarded by American Heart Association

Awarded by British Heart Foundation

Awarded by DFG

Awarded by FP7/2007-2103 European Union project CVgenes@ target

Awarded by NATIONAL CANCER INSTITUTE

Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE

Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Awarded by NATIONAL INSTITUTE ON AGING

Awarded by National Institute on Minority Health and Health Disparities

Funding Acknowledgements

The work was supported by the following grants: National Institute of Health grants: R21HL123677, R21-HL140385, DK104806-01A1, R01-MD012765-01A1 (NF), National Institutes of Health awards R01HG009120, R01HG006399, U01CA194393, T32NS048004 (CG), the American Heart Association Grant #17POST33350042 (PV), the British Heart Foundation (RG/13/5/30112) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre (RCL and RPH), the British Heart Foundation FS/14/55/30806 (JCH), the German Federal Ministry of Education and Research (BMBF) in the context of the e:Med program (e:AtheroSysMed), the DFG as part of the CRC 1123 (B3), and the FP7/2007-2103 European Union project CVgenes@ target (grant agreement number Health-F2-2013-601456). We thank Li-Ming Gan for assistance with the STARNET study and Jon White for assistance with UCLEB analyses. Additional acknowledgements are included in Supplementary Note 2.