Early Skeletal Muscle Loss in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation and Relationship to Survival
Nicole Kiss, Julian Beraldo, Sarah Everitt
SUPPORTIVE CARE IN CANCER | SPRINGER | Published : 2019
PURPOSE: Sarcopenia is associated with reduced survival in cancer. Currently, data on sarcopenia at presentation and muscle loss throughout treatment are unknown in patients receiving chemoradiation therapy (CRT) for non-small cell lung cancer (NSCLC). This study evaluated skeletal muscle changes in NSCLC patients receiving CRT and relationship with survival. METHODS: Secondary analysis of 41 patients with NSCLC treated with CRT assessed for skeletal muscle area and muscle density by computed tomography pre-treatment and 3 months post-treatment. Images at week 4 of treatment were available for 32 (78%) patients. Linear mixed models were applied to determine changes in skeletal muscle over ti..View full abstract
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Awarded by National Health and Medical Research Council
This work was supported by a National Health and Medical Research Council New Investigator Project Grant (APP1003895) and a Victorian Cancer Agency Tumour Stream Research Grant (both SJE).