Determination of the minimum protective dose of a glycoprotein-G-deficient infectious laryngotracheitis virus vaccine delivered via eye-drop to week-old chickens
Mesula G Korsa, Joanne M Devlin, Carol A Hartley, Glenn F Browning, Mauricio JC Coppo, Jose A Quinteros, Carlos A Loncoman, Adepeju E Onasanya, Dulari Thilakarathne, Andres Diaz-Mendez
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
Infectious laryngotracheitis (ILT) is an upper respiratory tract disease of chickens that is caused by infectious laryngotracheitis virus (ILTV), an alphaherpesvirus. This disease causes significant economic loses in poultry industries worldwide. Despite widespread use of commercial live attenuated vaccines, many poultry industries continue to experience outbreaks of disease caused by ILTV. Efforts to improve the control of this disease have resulted in the generation of new vaccine candidates, including ILTV mutants deficient in virulence factors. A glycoprotein G deletion mutant vaccine strain of ILTV (ΔgG ILTV), recently licenced as Vaxsafe ILT (Bioproperties Pty Ltd), has been extensivel..View full abstract
This work was funded by the Poultry Cooperative Research Centre through Sub-Project 1.1.10 awarded to project leader Joanne M Devlin and was funded by the Asia Pacific Centre for Animal Health. Mesula G. Korsa was supported by Australian Government Research Training Program (RTP) scholarship. There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Mesula G. Korsa was supported by Australian Government Research Training Program (RTP) scholarship. This work was partially funded by the Australian Poultry Cooperative Research Centre. We thank Dr. Pollob Shil, June Daly and Janece Wheeler for providing care for the animals. We thank Bioproperties Pty Ltd, and particularly Dr Greg Underwood, for support, advice and valuable discussions.