Journal article

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation

undefined Vivax Sporozoite Consortium, Ivo Muller, Aaron Jex, Stefan I. Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, Michael Duffy Show all

Published : 2017

Abstract

ABSTRACT Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form resilient hypnozoites (sleeper-cells) in the host liver that escape treatment and cause relapsing infections. The decision to form hypnozoites is made early in the liver infection and may already be set in sporozoites prior to invasion. To better understand these early stages of infection, we undertook a comprehensive transcriptomic and histone epigenetic characterization of P. vivax sporozoites. The salivary-gland sporozoite transcriptome is heavily composed of transcripts associated with functions needed for early infection of the vertebrate host and dev..

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