Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo
Robert K Shepherd, Paul M Carter, Ya Lang Enke, Andrew K Wise, James B Fallon
JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2019
OBJECTIVE: Although there are useful guidelines defining the boundary between damaging and non-damaging electrical stimulation they were derived from acute studies using large surface area electrodes in direct contact with cortical neurons. These parameters are a small subset of the parameters used by neural stimulators. More recently, histological examination of cochleae from patients that were long-term cochlear implant users have shown evidence of particulate platinum (Pt). The pathophysiological effect of Pt within the cochlea is unknown. We examined the response of the cochlea to stimulus levels beyond those regarded as safe, and to evaluate the pathophysiological response of the cochle..View full abstract
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Awarded by National Institute on Deafness and Other Communications Disorders
Awarded by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
This work was supported by the National Institute on Deafness and Other Communications Disorders (R01DC015031) and Cochlear Ltd. The Bionics Institute acknowledges support of the Victorian Government through Operational Infrastructure Support Program. We thank Dr A Thompson, C Singleton, E Trang, C McGowan, B Flynn, V Maxim, H Feng, J Zhou, N Critch, C Gaunt, Dr T Nguyen, C Grenness from the Bionics Institute, R Curtain from the SEM Facility at Bio21, University of Melbourne for their excellent technical assistance, Dr Pavel Takmakov and Prof John Furness for advice on aspects of this study, and staff at the National Measurement Institute of the Australian Government for ICP-MS analysis.